SC5: Humanized Mouse Models: Technology and Applications in Preclinical Assessment of Cancer Immunotherapy
29 NOVEMBER 2018 | 19:00-21:30
The development of severely immunodeficient IL2r null mice that support engraftment of functional human immune systems has enabled the in vivo study of human immunity. This presentation will include a general overview of these humanized mouse models, describing currently available strains, the protocols to generate humanized mice, the strengths of each system and a discussion of the application of these models to study human immunology.
Instructor:
Michael Brehm, Ph.D., Associate Professor, The Robert and Sandra Glass Term Chair in Diabetes, Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School
Topics to be Discussed:
- Selection of appropriate mouse strains
- Applications for humanized mice
- Humanized models available
- Human immune system development in humanized mouse models
- Next generation mouse strains
Instructor Biography:
Michael Brehm, Ph.D., Assistant Professor, Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School
Dr. Brehm received his Ph.D. from the Department of Microbiology and Immunology at the Pennsylvania State University College of Medicine. He is currently an Assistant Professor in the Program in Molecular Medicine at the University of Massachusetts Medical School and a member of the UMass Diabetes Center of Excellence. Dr. Brehm’s research program is focused on understanding how human effector T cells are regulated, and his laboratory is actively using “humanized” mice to model human T cell responses. Dr. Brehm has published over 70 manuscripts and reviews and is supported by funding from the JDRF, NIAID, NIDDK and the Helmsley Charitable Trust.